Design of a Numbering-up System of Monolithic Microreactors and Its Application to Synthesis of a Key Intermediate of Valsartan
Nagaki, A.; Hirose, K.; Tonomura, O.; Taga, T.; Taniguchi, S.; Hasebe, S.; Ishizuka, N.; Yoshida, J.
Org. Process Res. Dev. 2016, 20, 687–691.
DOI: 10.1021/acs.oprd.5b00414
The productivity improvement was demonstrated in the Suzuki coupling reaction using a catalytic column reactor by numbering up through parallelization of the reactors. A valsartan precursor was synthesized.
