Asymmetric Carbolithiation of Conjugated Enynes: A Flow Microreactor Enables the Use of Configurationally Unstable Intermediates before They Epimerize.
Tomida, Y.; Nagaki, A.; Yoshida, J.
J. Am. Chem. Soc. 2011, 133, 3744–3747.
DOI: 10.1021/ja110898s
The reaction of conjugated enynes with aryllithiums generated configurationally unstable alkyl lithium, which can be reacted with electrophiles before they epimerize due to flow microreactors.
