Stille, Heck, and Sonogashira coupling and hydrogenation catalyzed by porous-silica-gel-supported palladium in batch and flow
Ashikari, Y.; Maekawa, K.; Ishibashi, M.; Fujita, C.; Shiosaki, K.; Bai, H.; Matsuyama, K.; Nagaki, A.
Green Process. Synth. 2021, 10, 722–728.
DOI: 10.1515/gps-2021-0069
With a column reactor, Sille reactions, Heck reactions, Sonogashira reactions, and hydrogenation were achieved. Scale-up was also demonstrated with a 1-hour continuous operation.
