One-flow operation via 4-bromopyridine enables flash synthesis of AChE inhibitor
Soutome, H.; Kimuro, Y.; Kawaguchi, T.; Yoo, D. E.; Yao, Y.; Oshida, S.; Nakayama, H.; Iwata, M.; Ebisawa, R.; Kikuchi, R.; Tomite, K.; Wada, S.; Ashikari, Y.; Nagaki, A.
Synthesis 2024, 56, 821–827.
DOI: 10.1055/a-2218-9048
Sequential desalination, lithiation, borylation, and cross coupling of 4-bromopyridine hydrochloride was achieved in one flow.
