Scaling-up of Suzuki coupling in catalyst reactor

publication
publication
bioactivecatalyst reactorcross couplingintegrationscale up

Flow grams-per-hour production enabled by hierarchical bimodal porous silica gel supported palladium column reactor having low pressure drop
Ashikari, Y.; Maekawa, K.; Takumi, M.; Tomiyasu, N.; Fujita, C.; Matsuyama, K.; Miyamoto, R.; Bai, H.; Nagaki, A.
Catal. Today 2022, 388–389, 231–236.
DOI: 10.1016/j.cattod.2020.07.014

Suzuki coupling reaction was carried out using a silica monolith column reactor, demonstrating the synthesis of 5 grams per hour of a pharmaceutical precursor.